The pathogenesis of Alzheimer's disease: the inflammation
Currently, more than 47 million people worldwide are living with dementia, and it is estimated that more than 10 million new cases occur each year. Alzheimer's disease (AD) is the leading and most common cause of dementia. To date, a growing number of studies have demonstrated that neuroinflammation is an important component of the pathogenesis of AD. The main factors associated with neuroinflammation include various cellular mediators such as microglia, cytokines, and chemokines. In addition, there is no specific treatment for AD, and it can only be alleviated by analyzing some symptoms associated with AD. However, the neuroimmunomodulator hypothesis seems to serve as a guide for finding new targets to develop effective treatments. This review describes the process of neuroinflammation and studies of neuroinflammation associated with AD and discusses some of the cells involved in neuroinflammation. The review also describes some of the current therapeutic approaches, the natural compounds curcumin and resveratrol, which can reduce inflammation. And can target Calhm2 and tau proteins to alleviate AD.
Proceedings of SPIE - The International Society for Optical Engineering
Li, Zihang, "The pathogenesis of Alzheimer's disease: the inflammation" (2023). Kean Publications. 377.