Comparison of cytokine mediators in type 2 inflammatory conditions on the skin and ocular surface
Purpose of reviewAs the conjunctiva is embryologically modified skin, ocular surface involvement can be observed in several atopic skin diseases. The purpose of this review is to highlight and compare the roles of type 2 cytokines in the skin and ocular surface, and their resulting disorders.Recent findingsAlthough there have been extensive studies identifying various type 2 cytokine pathways in the skin, there is limited analyses of pathways assessed on the ocular surface. We provide the potential overlapping cytokine impacts on the skin and eye including interleukin (IL)-4, IL-5 IL-13, IL-25, IL-33, thymic stromal lymphopoietin (TSLP), and IL-31 that may provide important immunomodulatory interventions and treatment for the more chronic and sight-threatening ocular disorders.SummaryDysregulation of type 2 inflammatory cytokines was found to elicit similar immunopathogenic responses on the skin and ocular surfaces, leading to barrier dysfunction, remodeling, immune cell recruitment, and symptoms such as pruritus.
Current Opinion in Allergy and Clinical Immunology
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Chen, Jamie and Bielory, Leonard, "Comparison of cytokine mediators in type 2 inflammatory conditions on the skin and ocular surface" (2022). Kean Publications. 531.