Title

MiR-302d Competitively Binding with the lncRNA-341 Targets TLE4 in the Process of SSC Generation

Authors

Yani Zhang, Yangzhou University
Wenhui Zhang, Yangzhou University
Cai Hu, Yangzhou University
Yingjie Wang, Yangzhou University
Man Wang, Yangzhou University
Qisheng Zuo, Yangzhou University
Ahmed Kamel Elsayed, Faculty of Veterinary Medicine
Yi Li, Wenzhou-Kean University
Bichun Li, Yangzhou University

Document Type

Article

Publication Date

1-1-2021

Abstract

MicroRNAs (miRNAs) are essential factors in the reproductive process of poultry. Here, we found miR-302d is a potential differentiation and negative factor of chicken embryonic stem cells (ESCs) into spermatogonia stem cells (SSCs). The competition mechanism was carried out for the preliminary exploration to determine the relationship among miR-302d, lncRNA-341(interacting with miR-302d), and target gene TLE4. The results showed that lncRNA-341 can competitively bind to miR-302d to decrease the targeted binding of miR-302d and TLE4 which promotes the differentiation of chicken SSCs. Moreover, it is suggested that miR-302d may participate in the Wnt signaling pathway through TLE4.

Publication Title

Stem Cells International

DOI

10.1155/2021/5546936

Recommended Citation

Zhang, Yani; Zhang, Wenhui; Hu, Cai; Wang, Yingjie; Wang, Man; Zuo, Qisheng; Elsayed, Ahmed Kamel; Li, Yi; and Li, Bichun, "MiR-302d Competitively Binding with the lncRNA-341 Targets TLE4 in the Process of SSC Generation" (2021). Kean Publications. 1080.
https://digitalcommons.kean.edu/keanpublications/1080