Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volumes 1-4. Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volumes 1-4.
Document Type
Article
Publication Date
1-31-2014
Abstract
Autophagy plays a direct or indirect role in health and disease. A simplified definition of autophagy is that it is an exceedingly complex process which degrades modified, superfluous (surplus) or damaged cellular macromolecules and whole organelles using hydrolytic enzymes in the lysosomes. It consists of sequential steps of induction of autophagy, formation of autophagosome precursor, formation of autophagosome, fusion between autophagosome and lysosome, degradation of cargo contents, efflux transportation of degraded products to the cytoplasm, and lysosome reformation.This chapter discusses specific functions of autophagy, the process of autophagy, major types of autophagy, influences on autophagy, and the role of autophagy in disease, immunity and defense.
Publication Title
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
First Page Number
1
Last Page Number
35
DOI
10.1016/B978-0-12-405529-2.00001-9
Recommended Citation
Hayat, M. A., "Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volumes 1-4. Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volumes 1-4." (2014). Kean Publications. 1976.
https://digitalcommons.kean.edu/keanpublications/1976