MESOPOROUS SULPHATE DOPED HYDROXYAPATITE NANOPARTICLES FOR CONTROLLED RELEASE OF PROTEINS

Document Type

Article

Publication Date

1-1-2022

Abstract

The purpose of this study is to synthesize and characterize the mesoporous nanostructure of Hydroxyapatite (HA), evaluate the impact of the addition of sulphate ions (SO42-) on the microstructure properties of HA, and assess the ability of the prepared materials to be used as a carrier for Bovine serum albumin (BSA) protein. This study successfully synthesized 0.07 mole of SO42- substituted HA using the reflux microwave-assisted wet precipitation method and fully characterized it using modern techniques. In particular, XRD, XPS, Raman, FESEM, and BET techniques were used to explore the micro-structure properties of materials. The results shows that the addition of SO42- ions amplified the lattice parameters and surface area of HA, and the particles shape was changed from semi-spherical to rod like shape. Adsorption and desorption of protein molecules were evaluated using BSA protein for 24 h at 37°C. BSA loading capacity and release behaviours were significantly improved with the incorporation of SO42- ions. The SO4- HA materials hold a promising future for being used as a carrier for protein molecules.

Publication Title

Ceramics - Silikaty

First Page Number

447

Last Page Number

452

DOI

10.13168/cs.2022.0040

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